vitamins effect on corona disease

                    Effect of vitamins for treating CoViD19 Patient

 Article by

H/Dr. Abdul Wahid Anwar,  

DHMS, FTJ. 

 Rawalpindi, Pakistan
   Email: wahidrwp@live.com,    

Skype Id: wahidwp 

Tweeter: AbdulWahidrwp

Role of vitamin A for CoViD19 patient    
  There are antioxidant vitamins (C, E and carotenoids) present in fruits and vegetables. The role of vitamin E is Free radical scavenging causing shielding is important. The children with vitamin, A deficiency are at increased risk for the development of respiratory diseases. Also according to the case history of asthma patients, it results in deficiency due to vitamin A.   
{Refer 1, 2, 3(Allen et al. (2009(Hazlewood et al., 2011) (Sommer et al., 1984)}.
        
Benefits for CoViD19 patient

• Vitamin A is useful for treating Asthma patients.
• regulation of immunity and innate.
• anti-inflammatory effect by resisting pro-inflammatory cytokines production i.e        TNF-α, which is a deficient state of vitamin A. 
•  The use of tomatoes and carrots causes an anti-asthmatic effect as mentioned in murine model.
  

{Refer 4,5,6,7  (Stephensen, 2001),(Villamor and Fawzi, 2005)(Aukrust et al.,2000)(Hazlewood et  al., 2011) }
Vitamin C for CoViD19 patient
It was observed in infected asthmatic mice, immunity increased in nonallergic Th1.Also reported by Jeong et al. in 2010 after an experiment on mice that the presence/intake of vitamin C causes a reduction in inflammation of the lung, resisting inflammatory cells in bronchoalveolar lavage in short called BALF and AHR.

                  {Refer 8,9 (Chang et al., 2009)  (Jeong et  al., 2010) }
Benefits for CoViD19 patient

• It performs anti-oxidant mechanisms i.e ascorbic acid by scavenging of aqueous radicals.
•  resistance to the incoming of inflammatory cells in BALF and reduces AHR.
• high concentration intake of vitamin C in BALF opposes eosinophilic infiltration.
• high concentration intake of vitamin C boosted ratio of Th1/Th2 cytokine secretion.
• immune resistance increase against allergic th1 immune response the Th1/Th2 balance toward.
• Boost immune system vs infection.

  {Refer 10,11.12 (Lee et  al., 2004)(Jeong et  al., 2010)(Wintergerst et al., 2006)}

Supplementation with vitamin C was also shown to stimulate the immune system in response to infection -in asthmatic patients, ascorbic acid intake reduces exercise-induced bronchoconstriction.
                             {Refer 13 (Tecklenburg et al., 2007)} Vitamin E for CoViD19 patient 
 Vitamins E performs free radical scavenging causing shielding.The vitamins which are famous as antioxidant vitamins (C, E and carotenoids) present in fruits and vegetables.   
                                                                       {Refer:1(Allen et al.(2009), }
The naturally existing antioxidant in vitamin E is tocopherols and tocotrienols.In acute respiratory syndrome (ARS) in animal models reduces with alpha (α)-tocopherol.

Occurrence of Tocopherols
They lies in

•  -vegetable oils
•  -nuts
•  -oils from corn
• -sesame
• -soybean and cottonseeds

Occurrence of Tocopherols

•  - palm oil

Benefits

•   -A case of study related tocotrienol for controlling oxidative stress considering COPD.     {Refer 14(A.Rahman, 2012)}.

•   -Vitamin E also resists asthmatic related problem by opposing the viability of allergen-specific IgE, Th2 cytokine production and mitochondrial dysfunction and also lipid mediators in the lung.      {Refer:15 (Mabalirajan et al., 2009)}.
  

•   -α-tocopherol therapy/uses reduce lung edema
•   - α-tocopherol  also controls lipid peroxidation
• The above two benefits as experimented with animals having acute respiratory syndrome.  

{Refer 16,17,18 (Demling et al., 1995)(Suntres and Shek, 1996 )(Fan et al., 2000)}

• -The experiments related to intake of α-tocopherol in animals reduces bleomycin-induced lung fibrosis.

         {Refer 20,21,22 (Kilinc et al., 1993)(Suntres and Shek, 1997)  (Deger et al., 2007)} .

• By the nebulization of gamma(γ)-tocopherol responded improvement in pulmonary functions experiments done on sheeps.  

•  γ-Tocopherol intake tested in animal show inhibition mucus cell hperplasia and eosinophilia while curing asthma and allergic rhinitis.  

• in allergen-sensitized animals, the intake of vitamin E opposes the effect in ozone-induced enhanced airway to be infected.           {Refer 23 (Chhabra et al., 2010)}

  



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References:

1. Allen, S., Britton, J.R., Leonardi-Bee, J.A., 2009. Association between antioxidant vitamins and asthma outcome measures: systematic review and meta-analysis. Thorax 64, 610–619.
2. Hazlewood, L.C., Wood, L.G., Hansbro, P.M., et al., 2011. Dietary lycopene supplementation suppresses Th2 responses and lung eosinophilia in a mouse model of allergic asthma. J. Nutr. Biochem. 22, 95–100. 
3. Sommer, A., Katz, J., Tarwotjo, I., 1984. Increased risk of respiratory disease and diarrhea in children with preexisting mild vitamin A deficiency. Am. J. Clin. Nutr. 40, 1090–1095.
4. Stephensen, C.B., 2001. Vitamin A, infection, and immune function. Annu. Rev. Nutr. 21, 167–192.
5.  Villamor, E., Fawzi, W.W., 2005. Effects of vitamin a supplementation on immune responses and correlation with clinical outcomes. Clin. Microbiol. Rev. 18, 446–464.
    
6. Aukrust, P., Muller, F., Ueland, T., et  al., 2000. Decreased vitamin A levels in common variable immunodeficiency: vitamin A supplementation in vivo enhances immunoglobulin production and downregulates inflammatory responses. Eur. J. Clin. Invest. 30, 252–259
    
7. Hazlewood, L.C., Wood, L.G., Hansbro, P.M., et al., 2011. Dietary lycopene supplementation suppresses Th2 responses and lung eosinophilia in a mouse model of allergic asthma. J. Nutr. Biochem. 22, 95–100.
    
8. Chang, H.H., Chen, C.S., Lin, J.Y., 2009. High dose vitamin C supplementation increases the Th1/Th2 cytokine secretion ratio, but decreases eosinophilic infiltration in bronchoalveolar lavage fluid of ovalbumin-sensitized and challenged mice. J. Agric. Food Chem. 57, 10471–10476
    
9. Wintergerst, E.S., Maggini, S., Hornig, D.H., 2006. Immune-enhancing role of vitamin C and zinc and effect on clinical conditions. Ann.  Nutr. Metab. 50, 85–94.
    
10. Tecklenburg, S.L., Mickleborough, T.D., Fly, A.D., et al., 2007. Ascorbic acid supplementation attenuates exercise-induced bronchoconstriction in patients with asthma. Respir. Med. 101, 1770–1778.
     
11. A.Rahman, I., 2012. Pharmacological antioxidant strategies as therapeutic interventions for COPD. Biochim. Biophys. Acta 1822, 714–728.
     
12. Mabalirajan, U., Aich, J., Leishangthem, G.D., et al., 2009. Effects of vitamin E on mitochondrial dysfunction and asthma features in an experimental allergic murine model. J. Appl. Physiol. 107,
    1285–1292
     
13. Demling, R., LaLonde, C., Ikegami, K., et al., 1995. Alpha-tocopherol attenuates lung edema and lipid peroxidation caused by acute zymosan-induced peritonitis. Surgery 117, 226–231.
    Suntres, Z.E., Shek, P.N., 1996. Treatment of LPS-induced tissue injury: role of liposomal antioxidants. Shock 6, S57–64
     
14. Fan, J., Shek, P.N., Suntres, Z.E., et al., 2000. Liposomal antioxidants provide prolonged protection against acute respiratory distress syndrome. Surgery 128, 332–338.
     
15. Kilinc, C., Ozcan, O., Karaoz, E., et al., 1993. Vitamin E reduces bleomycin-induced lung fibrosis in mice: biochemical and morphological studies. J. Basic Clin. Physiol. Pharmacol. 4, 249–269.
     
16. Deger, Y., Yur, F., Ertekin, A., et al., 2007. Protective effect of alphatocopherol on oxidative stress in experimental pulmonary fibrosis in rats. Cell Biochem. Funct. 25, 633–637.
     
17. Chhabra, S.K., Yasir, A., Chaudhry, K., et al., 2010. Effect of ozone on response to ovalbumin & its modulation by vitamins C & E in sensitized guinea pigs. Indian J. Med. Res. 132, 87–93.