Nigella Sativa for corona treatment

 Black Seed or Nigella Sativa for corona treatment

 Article written by

 H/Dr. Abdul Wahid Anwar,
DHMS, FTJ.
Rawalpindi, Pakistan
Email:wahidrwp@live.com,scienceonics@gmail.com 
Skype: wahidrwp 

Introduction of Black seed or Nigella Sativa 
According to the global institute of asthma (GIA) declared  asthmatic symptoms as

• heterogeneous disease
• chronic airway inflammation
• wheeze
• shortness of breath
• chest tightness
• cough

These above symptoms intensity changes with the passage of time.
                                                
 Black seeds ( Nigella Sativa )  commonly used in herbal treatment in several diseases.In research work, it was also observed that Nigella Sativa showed effective results against asthmatic inflammation.   
                           
The famous Muslim Scholar named as Imam Ibn Qayyim al Jawziyya (1292–1350 CE) wrote in accordance with Prophetic(P.B.U.H) Medicine that this black seed (NS) is a curing medicine for the difficulty in breathing.       
            
In Arab, black seed or Nigella Sativa also taken for curing/treating cough and asthma.(Lebling and Pepperdine, 2006). The thymoquinone belonged to Nigella Sativa and extracted from Nigella Sativa oil by El–Dakhakhny about 1963.
                                                                                        
 Asthma is initiated by multiple interactions between inflammatory cells and mediators and it affects the lungs, hyperactivity of muscle smoothness and mucus hypersecretion.According to global asthma physician and patient(GAPP) conducted a survey in about 2005, It was reported that 76% of the asthmatic patients and 81% of Physicians preferred that there must be some other treatment than the current treatment.   

Experimental Work on Black seed ( Nigella Sativa )

Pre-clinical studies of Nigella sativa in cellular and animal models of asthma

 Anti-inflammatory and immunomodulatory results

Black seed or Nigella Sativa and compound-related are thymoquinone, alpha hederin and nigellone on asthmatic animal models (18 in number) and a the single asthmatic human cellular model showed in seven studies with anti-inflammatory and immunomodulatory results.    
 
Relaxant effect or bronchodilatory
 In six studies, the Black Seed  or Nigella Sativa (NS) extracts, thymoquinone or a-hederin delivered a relaxant effect or bronchodilatory.

 Anti-histaminic result
  In Four studies related to Nigella Sativa oil or extract of aqueous form, nigellone or alpha-hederin provided anti-histaminic results.The Pathological betterment was recognized in five studies when thymoquinone was applied.

Nigella sativa clinical studies in asthmatic patients
 
An effective results of a Black Seed or Nigella Sativa (NS) related to seven clinical studies of biomarkers and asthma.After the application of seeds powder (crushed) or may be in the form of oil extract in two (RSBPCT) and three (RDBPCT) Black Seed or Nigella Sativa (NS) caused betterment / impressive results on adults asthmatic patients in pulmonary function test (PFT). In addition, a reduction of blood eosinophilia was found in RDBPCT.Also in RDBPCT, blood eosinophilia decreased.

Uses / benefits
According to the clinical effect/uses of the Nigella Sativa.It has following features.

• cellular models of asthma including bronchodilation.
• anti-inflammatory
• anti-leukotrienes
• anti-histaminic
• immunomodulatory effects
• reduction of blood eosinophilia.
• antioxidant effect                                             
• chemopreventive activity    
•  exceptional anticancer activity
• The thymoquinone in stomach inhibiting benzo(a) pyrene-induced carcinogenesis when experimented in a mouse model.     
• The thymoquinone (TQ) is resisting behavior achieved against an increase in proliferation of numerous cell lines.
• The thymoquinone (TQ) opposes the growth of mitogen-activated protein kinase (MAPK) and protein kinase B (AKT/PKB).
• The molecules related to Nigella Sativa(NS) consisting of the ability for having the activity for antitumor and increased permeability of the membrane.  

In North Africa it  has been applied to the following diseases/symptoms:

• bronchitis
• headache,
• rheumatism
• fever
• cough
• influenza
• eczema        

Suggestions:
 The use of black seed or Nigella Sativa is useful for the patient suffering from corona disease or CoViD19 . Also in accordance with the asthmatic patient and doctors survey held in about 2005 of global asthma physician and patient or GAPP on average about 76% were interested in new treatment for asthma.
 The use of black seed with honey will be effective for corona patient.


How to use:

Take 1 gram of black seed or Nigella Sativa with two spoons 4 or 5 times in a day.
  
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References:

• Abdul Rahman Koshak, Emad Koshak, Michael Heinrich;  Medicinal benefits of Nigella Sativa in bronchial asthma: A literature review; Saudi Pharmaceutical Journal; 25 1130–1136 (2017).

• Global Initiative for Asthma, 2017

•  bhanu. Gupt et al. "Thymoquinone";journal name:nutraceuticals DOI:http://dx.doi.org/10.1 /B978-0-12-802147-7.00039-5; 2016.

• J.P.Dzoyem et al. “Anti-inflammatory and Anti-nociceptive Activities of African” Medicinal Spices and Vegetables from Africa.http://dx.doi.org/10.10/B978-0-12-809286-6.00009-1,2017